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Cholinesterase inhibitors, commonly used to treat dementia, could cause older adults to lose a “harmful” amount of weight, new research suggests.

University of California–San Francisco researchers compared data from a group of seniors. After 12 months, 29.3% of the patients on inhibitors had “significant” weight loss of 10 or more pounds, compared to 22.8% of patients on other medications. 

Weight loss is a common problem in dementia patients, the researchers wrote in the August issue of the Journal of the American Geriatrics Society.